EFEK PEMBERIAN EKSTRAK ETANOL RIMPANG JERINGAU TERHADAP GAMBARAN MORFOHISTOLOGI GINJAL TIKUS PASCA INDUKSI NATRIUM NITRIT

<p class="abstrak">Long-term use of NaNO<sub>2</sub> in food preservatives causes a variety health problems, particularly for kidney function. Natural antioxidants that can reduce the effects free radicals are required to prevent these effects. The sweet flag plant is medicinal with high antioxidant potential. This study aims determine effect rhizome extract (SFRE) on morphology and histology kidneys white rats induced by NaNO<sub>2</sub>. used 25rats 5 groups. Negative control was given CMC0,5% 40 days, positive NaNO2. dose 50 mg/kgBW days 1-30 CMC0.5% 16-40, treatment groups 1, 2 3 were Dosage 1-15, 16-30 NaNO2 mg/kg BW+SFRE, 31-40 only SFRE graded doses (T1=250,T2=500, T3=750 mg/kgBW). results obtained include has no morphology. However, affects diameter distal proximal tubules both getting Pvalue=0.000. had an score histological damage Pvalue=0.017. safe optimal improve renal 250 BW.</p>